Report of the Portfolio Committee on Health on an oversight visit to Charlotte Maxeke Johannesburg Academic Hospital on 21 may 2010, dated 20 July 2010

 

The Portfolio Committee on Health having undertaken an oversight visit to Charlotte Maxeke Johannesburg Academic Hospital on 21 May 2010 reports as follows:

 

1. INTRODUCTION

 

The Portfolio Committee on Health has an oversight role over the Department of Health.  The vision of the committee is to ensure an accessible, affordable, equitable, quality, effective and efficient health system for all the people of South Africa.  It can no longer be business as usual when the people of South Africa do not have access to an effective and efficient health system.

 

2.       OBJECTIVES OF THE VISIT

 

There had been an infection outbreak at Charlotte Maxeke Johannesburg Academic Hospital which led to the deaths of 6 babies by 18 May 2010. The committee wanted to assess the situation and see whether there was a threat of the infection spreading to other hospitals and provinces. The committee also wanted to evaluate the strategies the hospital was using in handling the infection so that it does not spread further. 

 

3.       DELEGATION

 

Dr MB Goqwana, Chairperson of the Committee (ANC), Ms E More (DA) and Ms V Majalamba (Committee Secretary).

 

4.       BACKGROUND

 

Dr Daynia Balldt who was in charge of the neonatal ward briefed the committee about the events that led to the death of the 6 neonates at Charlotte Maxeke Johannesburg Academic Hospital. She informed the committee that the first baby had diarrhoea on Friday, 14 May 2010 but his condition then improved. Thirteen babies were sick on Saturday, 15 May 2010 and by Sunday the number had increased to seventeen. The 5 neonates died on Monday, 17 May 2010 and the sixth one died in the evening of Tuesday, 18 May 2010.

 

Dr Balldt stated that the babies were admitted to 3 different wards but were sick at the same time. They were then admitted to 1 ward. She told the committee that the hospital had never had an outbreak like that before and further indicated that the hospital was once rated a world class hospital. She stated that she was very concerned over the bad reports by the media. She indicated that staff has to be acknowledged for the good job they did during the outbreak instead of blaming them. She also admitted that there were challenges like overcrowding in the ward and staff shortages and that most of the staff did not want to work at the neonatal ward because of the heavy workload.

 

She mentioned that there were forty five neonates in the ward while the capacity of the ward was thirty five. She told the committee that there was no way they could have avoided overcrowding or they would have been in breach of the Constitution of South Africa which states that everybody has the right to access to health care services and because most of the neonates were born at the hospital there was no way they could have chased them away after birth. She also told the committee that they were faced with financial constraints but that they were doing their best with what they had. 

 

Dr Balldt further informed the Committee that they had initially suspected that the outbreak and deaths were due to pre-Nan Feeds. The majority of the babies were premature varying from low to very low birth weights. The hospital then called the National Health Laboratory Services to conduct an investigation on what might have been the cause of the deaths of the babies.

 

5.       INVESTIGATIONS BY THE NATIONAL HEALTH LABORATORY SERVICES (NHLS)

 

Dr Balldt stated that on Sunday, 16 May 2010 Professor AG Duse who worked for the National Health Laboratory Services and the Wits University was called to assist with an outbreak of diarrhoea occurring predominantly in premature neonates in the neonatal wards numbers 177 and 184 at the Charlotte Maxeke Johannesburg Academy Hospital. There were seventeen neonates who were affected at that stage. Dr Balldt informed the committee that pre-term and particularly very low birth weight neonates are vulnerable to infections and complications, due to the fact that their immune system was immature.

 

Sixteen faecal samples were submitted for virology investigations and fifteen of these tested positive for Norovirus. She indicated that Noroviruses have been documented as causes of neonatal diarrhoea that can become complicated to more serious and potentially life-threatening conditions such as extensive inflammation and damage and death of cells in the gastrointestinal tract (necrotising enterocolitis). In premature neonates, severe inflammation of the gastrointestinal tract can lead to both resident and hospital-acquired gut bacteria migrating into the bloodstream causing severe sepsis and even death of the infant. 

 

Dr Balldt stated that line-listing was done with all affected neonates. An audit with on-site infection prevention and control, training and education was carried out in wards 177 and 184.  Nineteen empty, used milk-fed bottles with evidence of residual milk were collected and sent to the National Health Laboratory Services Infection Prevention and Control Laboratory for culture. She further stated that twelve of these bottles grew klebsiella pneumonia but they were still awaiting the antibiogram which would be available by Thursday, 20 May 2010. A further 6 grew a gram-negative bacillus morphologically resembling klebsiella but they were awaiting final confirmatory identification and antibiogram results. One bottle grew a gram-negative bacillus to be further identified. 

 

Four reconstituted milk-fed bottles were collected and sent to the NHLS Infection Prevention and Control Laboratory for culture. One of these bottles grew a gram-negative bacillus morphologically resembling klebsiella but they were also awaiting the final confirmatory identification and antibiogram results which would be available by Thursday, 20 May 2010. 

 

Thirteen rectal swabs and 4 stool samples were collected in duplicate (a total of 4 specimens) from symptomatic neonates for bacteriology and virology investigations. Of the seventeen sent for microbiology, fifteen grew a gram-negative vacillus morphologically resembling klebsiella but the hospital was still awaiting final confirmatory identification. Of the sixteen received by the National Institute for Communicable Disease (NICD) for virology, fifteen tested positive for the norovirus.

 

 

Faecal samples collected from the seventeen neonates that were sent for bacteriological investigation yielded a growth in fifteen of the seventeen samples of a bacterium called klebsiella pneumonia, 6 of which were highly resistant to antibiotics and called ESBL positive strains. Dr Balldt further mentioned that it is important to note that both drug sensitive strains of klebsiella pneumonia were present in the blood of at least 4 of the 8 neonates from whom blood cultures were collected suggesting possible migration (translocation) of gut organisms into the bloodstream. Eighteen used milk bottles were processed and in all of these klebsiella pneumonia was found, thirteen strains of which were highly drug-resistant. 

 

Two patients discharged from the neonatal wards on Friday, 14 May 2010 were readmitted with diarrhoea to ward 285 where blood cultures were taken on 18 and 19 May 2010. One blood culture grew a drug-sensitive klebsiella and the other a bacterium that needed further identification. Furthermore, two blood cultures from 2 new babies were collected on 18 May 2010 and tested positive for bacteria growth (microbes needed to be identified further).

 

 

6.       FINDINGS BY THE NATIONAL HEALTH LABORATORY SERVICES (NHLS)

 

  • The norovirus may have been introduced from the community and it infected one or more neonates. It spread to all other babies due to lack of infection prevention and control practices.
  • Gastrointestinal damage caused by the norovirus might have led to migration of gut organisms like klebsiella pneumonia and other bacteria into the bloodstream and caused severe sepsis requiring the administration of antibiotics into the bloodstream.
  • Bacteria that were present in the gut can furthermore be spread by contaminated hands due to inadequate handwashing after diaper changes and in the course of healthcare delivery to other neonates and result in healthcare associated infections.
  • The bacterially contaminated used milk bottles could have also led to the introduction of dangerous bacteria into the very fragile gastrointestinal tract of the pre-term neonates with norovirus diarrhoea and could have caused complications such as necrotising enterocolitis. 

 

Investigations conducted suggested that more than one (probably all four) of the above contributed to the outbreak.

 

The hospital believed that it was most likely that the virus was introduced into the neonatal ward by caregivers (mothers), siblings or healthcare personnel.

 

7.       INTERVENTIONS BY THE HOSPITAL

 

  • Education and training on proper infection control measures was done immediately for all ranks of staff in ward 177 and in the milk kitchen.
  • Continuous and unannounced inspections were being carried out.
  • All the babies from the neonatal ward were moved to the newly renovated ICU, with single cubicles while the ward was being disinfected and made safe for patient care again.
  • The milk kitchen was thoroughly cleaned and disinfected and renovations would be carried out before the end of that week.
  • Professor Duse from the National Health Laboratory Services (NHLS) will continue to monitor laboratory results.
  • Visits by parents were monitored and protective clothing were provided for them before they were allowed to see their babies.
  • All staff members working in the neonatal unit were being supplied with disposable surgical gowns and caps.
  • Counselling was arranged for the bereaved mothers. 

 

 

 

8.       WALK ABOUT AT THE HOSPITAL

 

 a)            PREM-UNIT (HIGH CARE UNIT)

 

The committee visited the prem-unit, where 6 neonates died. There were no neonates at the ward because all were removed to the newly renovated ICU after the outbreak. The committee observed that the infrastructure was very old. The CEO, Dr Barney Selebano informed the committee that the ward was going to be renovated, cleaned and de-germed.

 

 b)            NEW ICU

 

The committee was informed that Carte Blanche donated money for the renovation of the unit. The purpose of the renovation was to extend the intensive care unit so that young and older children were not admitted to the same ward. The unit was where all the neonates were admitted from the prem-unit. The committee observed that the unit was very clean and had disposable gowns and gloves that were used by the staff and people visiting the unit. The committee further noted that all children were in single cubicles.

 

 c)            LABOUR WARD

 

The committee was shown where the babies were delivered. There was a four bedded unit at the labour ward that was called the transitional unit for neonates. Babies were screened at the unit and if found sick they were referred to the ICU, otherwise they were referred to the prem-unit. The committee was informed that there were two nurses per shift.

 

 d)            MILK ROOM

 

The committee observed that the milk room was in a bad condition. The infrastructure was very old and bottle brushes were used that were very old and rusty.

 

 

9.       FINDINGS BY THE COMMITTEE 

 

The committee concluded its visit and noted that the hospital was short staffed. Another key finding was that the hospital was under funded hence they were still operating on a very old infrastructure.

 

 

10.         RECOMMENDATIONS

 

The Committee recommended that:

 

a)     Communities and children should be immunised and fully vaccinated especially towards winter season.

b)     Community based education and preventative measures be scaled up especially on the basics like cleanliness and washing of hands.

c)      Parents visiting neonates should be monitored at all times.

d)     Counselling be arranged for staff members that were working at the neonatal ward when the incident happened.

e)     Radical action be taken by the health sector to strengthen the quality of child care.

f)        Milk rooms be moved to the neonatal ward or closer so as to enable health professions staff to be involved. 

g)     The issue of staff shortages and inadequate funding of the hospitals be dealt with as a matter of urgency by the National Department of Health.

h)      The Department needs to strengthen and promote Primary Health Care.

i)        Tertiary institutions be run and managed by the National Department of Health as one of the strategies to manage the referral system.